Dr. Paul Hyman
Dr. Paul Hyman came to Ashland University in 2010. He has taught at MedCentral College of Nursing (now the AU Dwight Schar College of Nursing and Health Sciences), and the Ohio State University. Before teaching, he did research at the Arizona Cancer Center, US Department of Agriculture, Tufts University and NanoFrames, a biotechnology startup.
My research centers on bacteriophages, viruses that infect bacteria. Bacteriophages are found wherever bacteria are found: essentially anywhere there are living organisms. Beyond being fascinating organisms, bacteriophages and bacteriophage proteins are also being developed as substitutes for antibiotics because bacteriophages often kill the bacteria they infect. The use of bacteriophages to treat bacterial infections is described as phage therapy. In my research group students are isolating and characterizing bacteriophages that infect Enterococcus faecalis, a bacterium that lives in healthy animals, including humans, but also causes opportunistic infections, especially in hospitals. We use these bacteriophages to study the infection process and as a source of new proteins that can be used to kill bacterial. Our long term goal is to better understand the evolution of bacteriophages, especially the evolution of how they gain access to new hosts, as well as the ways bacteria protect themselves from being infected and killed. The mechanisms of this evolution have implications for the use of bacteriophages in phage therapy.
I work in...
Biology and Toxicology at Ashland University
When you choose a Biology Science major at Ashland University, you join a program on the cutting edge of scientific exploration with outstanding facilities and research equipment, access to five local nature preserves, strong... Read More